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Dacryocystitis
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Introduction
  • Inflammation of the lacrimal sac or nasolacrimal duct.
  • Cause : usually foreign body or bacterial infection.
  • Signs : unilateral copious mucopurulent discharge.
  • Diagnosis : clinical signs, cannulation and flushing of nasolacrimal duct, dacryocystorhinography.
  • Treatment : nasolacrimal flush, antibiotic therapy and/or cannulation of nasolacrimal duct.


Presenting signs
  • Copious mucopurulent ocular discharge that does not resolve following topical antibiotic therapy.
  • Unilateral or bilateral.


Cost considerations
  • Moderate: when anesthesia is necessary for dacryocystorhinography, dacryocystotomy, or cannulation.
  • Low: when flushing and antimicrobial therapy are adequate.
Pathogenesis Top

Etiology
  • Foreign bodies within the nasolacrimal system, eg grass awn.
  • Bacterial conjunctivitis with extension into the nasolacrimal sac or duct. Most common isolates are Staphylococcus Staphylococcus spp , Streptococcus Streptococcus spp , E. coli Escherichia coli , Enterobacter Enterobacter aerogenes (aerobacter aerogenes) , Pseudomonas Pseudomonas , and Proteusspp Proteus spp.
  • Dental disease with extension of infection from the tooth root into the nasolacrimal duct.
  • Infection secondary to other obstructions of the duct, eg trauma, tumor, stenosis, cysts, etc.
  • Rarely, fungal infections of the nasolacrimal duct.


Predisposing factors
General
  • Outdoor or hunting dogs for foreign bodies Eye: ocular foreign body.


Pathophysiology
  • Inflammation of the lacrimal sac or nasolacrimal duct.
  • Presence of foreign body results in inflammation and secondary bacterial infection.
  • Bacterial infections may extend into the nasolacrimal sac and duct from adjacent tissues.


Timecourse (incubation, duration)
  • Symptoms may develop in 5-7 days.
  • Duration may be prolonged because the disease is often unresponsive to topical antibiotics.

Diagnosis Top

Presenting problems
  • Purulent ocular discharge.


Clinical signs
  • Mucopurulent to purulent ocular discharge.
  • Often unilateral.
  • Pressure on the medial canthus results in purulent material extruding from the lower punctum.
  • Occasional swelling over the lacrimal sac just beneath the medial canthus; may be painful.
  • Excoriation of the skin near the medial canthus from accumulation of ocular discharge.


Diagnostic investigation

Ophthalmic examination

  • To rule out other causes of purulent ocular discharge, such as ulcerative keratitis Keratitis , keratoconjunctivitis sicca Keratoconjunctivitis sicca , bacterial conjunctivitis Conjunctivitis.
  • To rule out epiphora and causes of epiphora Epiphora.
  • Fluorescein stain Fluorescein test applied to the cornea does not appear at the nose or the back of the throat. This test does not confirm blockage of the nasolacrimal duct in all animals, however, and is not diagnostic of dacryocystitis.
Microbiology
  • Bacterial culture of discharge expressed from the lower punctum.

Cannulation

  • Cannulation and flushing of the nasolacrimal duct is the easiest method to confirm dacryocystitis.
  • A nasolacrimal cannula is inserted into the upper punctum and saline is flushed into the cannula, observing for purulent or foreign material to extrude from the lower punctum.
  • After flushing the upper puncta, the lower punctum is cannulated and the upper punctum is occluded with digital pressure. The cannula is flushed with saline and the nose is observed for passage of purulent material and foreign debris.
  • Resolution of signs after flushing and administration of topical antibiotics may confirm the diagnosis.

Radiography

  • Plain radiographs of the skull Radiography: skull (basic) taken under general anesthesia may be helpful in identifying tooth root disease, bony lysis or proliferation, cystic changes in the area of the lacrimal sac, and nasal disease.

Dacryocystorhinography

  • Is sometimes required to confirm the diagnosis and identify a cause.
  • Plain radiographs of the skull are taken with the animal under anesthesia. If no abnormalities are found, then a positive contrast procedure is performed.
  • One-half to two milliliters of aqueous positive contrast material (eg Hypaque) is infused into the upper punctum using a lacrimal cannula or catheter, while the lower punctum is occluded.
  • Lateral (affected side up) and dorsoventral radiographs are repeated after the infusion.
  • Helps to identify distention of the nasolacrimal sac; abnormal position, deviation, dilatation, rupture or stenosis of the duct; and sometimes abnormalities of the canaliculi.


Confirmation of diagnosis
Discriminatory diagnostic features
  • History.
  • Clinical signs.
  • Ophthalmic examination.

Definitive diagnostic features
  • Nasolacrimal duct flushing: non-patency or foreign body flushed from duct, resolution of signs after flushing.
  • Dacryocystorhinography.
  • Dacryocystotomy.


Differential diagnosis
  • Keratitis Keratitis.
  • Conjunctivitis Conjunctivitis.
  • Epiphora Epiphora.
  • Keratoconjunctivitis sicca Keratoconjunctivitis sicca.

Treatment Top


Standard treatment
  • Nasolacrimal flushing is performed as outlined above and followed by a topical antibiotic solution.
  • Systemic antibiotics may also be needed for evidence of nasal or dental disease, excoriation of the skin, etc.
  • Non-responsive cases may require treatment via an indwelling nasolacrimal cannula:
    • Polyethylene, silastic or polyvinyl catheter tubing is inserted and sutured to the skin of the face, adjacent to the medial canthus and nares.
    • Cannula is left in place for at least 3 weeks.
    • Uncannulated punctum isflushed with antimicrobial agent Therapeutics: eye.
    • Topical antibiotic solutions are continued and are sometimes combined with topical steroids.
  • Dacryocystotomy may also be considered in refractory cases, especially if a foreign body may be lodged in the lacrimal sac.
    • Involves opening the lacrimal sac by drilling through the bone over lying the area.
    • The sac is cannulated and a catheter is left in place prior to surgically opening the sac to help in identification of the sac. The sac is entered, flushed and any foreign material is removed.
    • It is then sutured closed with the cannula left in place, and followed by topical and systemic antibiotics.


Subsequent management

Sequelae Top
Prognosis
  • High recurrence rate with short term therapy and only one flushing procedure.
  • Multiple flushings may be performed at weekly intervals for 2-3 treatments.


Expected response to treatment
  • Decreased purulent discharge and discomfort within a 1-2 days after flushing.


Reasons for treatment failure
  • Inability to cannulate due to stricture or to establish patency of the duct.
  • Inability to flush out or remove a foreign body.
  • Misdiagnosis of dental disease.
  • Infection secondary to nasal disease or nasal tumor.
  • Failure to recognize the presence of rare fungal infections.
  • Inadequate length of treatment.
  • Inappropriate choice of antibiotic.

Sources Top
Publications
Refereed papers
  • Recent references from PubMed.
  • Whitley R D (2000) Canine and feline primary ocular bacterial infections. Vet Clin North Am Small Anim Pract 30 , 1151-1167.
  • van der Woerdt A, Wilkie D A, Gilger B C et al(1997) Surgical treatment of dacryocystitis caused by cystic dilation of the nasolacrimal system in three dogs. JAVMA 211 , 445-447.
  • Laing E J, Spiess B & Binnington A G (1988) Dacryocystotomy - a treatment for dacryocystitis in the dog. JAAHA 24 , 223-226.
  • Lavach J D, Severin & G A Roberts (1984) Dacryocystitis - a review of 22 cases. JAAHA 20 , 463
  • Johnston G R, Feeney D A (1980) Radiology in ophthalmic diagnosis. Vet Clin North Am Small Anim Pract 10 , 317-337.

Other sources of information
  • Munger R J (2002) Disorders of the lacrimal and nasolacrimal system. In: Morgan R V, Bright R N, Swartout M S (eds) Handbook of Small Animal Practice. 4th Ed. W B Saunders, Philadephia, pp. 954-963.



Vetstream contributor(s)
  • Dr Paul Gerding DVM MS DipACVO , Department of Veterinary Clinical Medicine, 1008 West Hazlewood Drive, Urbana, IL 61802-4795, USA.
  • Dr Rhea V Morgan DVM DACVIM DACVO , Smoky Mountain Veterinary Services, Walland TN, USA

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Conjunctivitis
Enterobacter aerogenes (aerobacter aerogenes)
Epiphora
Escherichia coli
Eye: ocular foreign body
Fluorescein test
Keratitis
Keratoconjunctivitis sicca
Nasolacrimal duct disease
Proteus spp
Pseudomonas
Radiography: skull (basic)
Staphylococcus spp
Streptococcus spp
Therapeutics: eye
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